# GLP-1 medicines for weight loss and diabetes: what you need to know

Source: https://www.keypedia.com/records/uk_mhra_guidance/uk-mhra/a253456f-cff0-48a7-ab59-c46071c0311c
Type: Guidance
Published: June 4, 2025
Updated: February 5, 2026

> The document provides a high-level overview of Glucagon-like peptide-1 receptor agonists (GLP-1s), such as Mounjaro, emphasizing their physiological function in appetite and blood sugar regulation. Within the relevant regulatory framework, the text highlights the distinction between medications authorized for weight loss and those marketed informally under media labels like 'weight loss injections.' While the provided excerpt does not specify a specific company name, inspection dates, or documented violations, it addresses the core issue of unauthorized use outside of official clinical indications. The required action for stakeholders is to verify that these medicines are used only for their authorized therapeutic purposes. This guidance aims to align clinical practice with regulatory approvals, ensuring that the popularity of these treatments does not lead to use in contexts where authorization has not been granted. By focusing on the hormonal mechanisms of these drugs, the text underscores the necessity of professional medical oversight and adherence to legal marketing authorizations, rather than following public trends or media characterizations that may misrepresent the intended use of the medication.

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## Content

Glucagon-like peptide-1 receptor agonists (GLP-1s or GLP-1RAs) are medicines that help people feel fuller by mimicking a natural hormone released after eating. Some newer medicines, like Mounjaro, also act on a second hormone involved in appetite and blood sugar control. You may see them referred to in the media as “weight loss injections” or “skinny jabs” but not all of these medicines are authorised for weight loss.

## Attachments

- [GLP-1 medicines for weight loss and diabetes: what you need to know](/government/publications/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know)