Detailed GuideMHRA
Clinical trials for medicines: apply for approval in the UK
How to apply for a clinical trial from 28 April 2026, including eligibility, documentation and registration in a public registry.
First published: Jun 24, 2025Last updated: Apr 27, 2026Changes: 6
Latest change: 1. Updated wording to give flexibility on location of information about the IMP 2. Clarified that only UK IMPDs can be cross-referenced The amended Clinical Trials Regulations took full effect on 28 April 2026. As such, this guidance should now be considered effective and is no longer in draft.
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